ABSTRACT
Background Asthma is still considered a major chronic respiratory disease that affects a large number in the world. The association between COVID-19 infection and asthma was studied in different ways focusing on hospital-admitted patients. This study aimed to assess the outcome of patients with asthma and/or COVID infection in adults attending outpatient pulmonary clinic over three successive months from clinical and laboratory point of view. Patients and methods The current study was a retrospective observational study involving 898 patients attending the outpatient pulmonary clinic of a Saudi Arabian private hospital over three successive months from the 1st of December 2020 to the end of February 2021. Patients were divided into three groups: group 1—COVID-19 infected with asthma (312);group 2—COVID-19 infected with no asthma (286);and group 3—COVID-19 non-infected with asthma (300). Results and conclusions Results showed the best patient's outcome was seen in asthmatic patients without COVID-19 infection followed by asthmatic patient with COVID-19 infection. There was a significant statistical difference in eosinophil count between COVID-19-infected patients with asthma and COVID-19 infected without asthma. Also, it was shown that the most common cause of hospitalization in asthmatic patients with COVID-19 infection was pneumonia followed by gastroenteritis and not an asthma exacerbation.
ABSTRACT
Objectives: This study evaluated the clinical manifestation of COVID-19 and adverse outcomes in patients with comorbidities (outcome: death). Methods: A comparative follow-up investigation involving 148 confirmed cases of COVID-19 was performed for a month (between April and May 2020) at Qaha Hospital to describe the clinical characteristics and outcomes resulting from comorbidities. Participants were divided into two clusters based on the presence of comorbidities. Group I comprised cases with comorbidities, and Group II included subjects without comorbidity. Survival distributions were outlined for the group with comorbidities after the follow-up period. Results: Fever (74.3%), headache (78.4%), cough (78.4%), sore throat (78.4%), fatigue (78.4%), and shortness of breath (86.5%) were the most prevalent symptoms observed in COVID-19 patients with comorbidities. Such patients also suffered from acute respiratory distress syndrome (37.8%) and pneumonia three times more than patients without comorbidities. The survival distributions were statistically significant (chi-square = 26.06, p ≤ 0.001). Conclusion: Multiple comorbidities in COVID-19 patients are linked to severe clinical symptoms, disease complications, and critical disease progression. The presence of one or more comorbidities worsened the survival rate of patients.